Abstract: As a kind of masonry material，compressive strength of self thermal insulation block foame concrete is one of the important factors that can meet national standards.Through literature review and preliminary test，it was screened as preparation of foamed concrete that hydrogen peroxide with concentration of 27% was used as foaming agent，cement and flyash as cementitious materials，calcium stearate and polycarboxylate as admixtures.Then the foamed concrete were compound which density of grade 200，250 and 300 as core material and that of grade 500，700 and 900 as the base material.Thickness of composite substrate was 25，30 and 35 mm respectively，using orthogonal design L9（34），nine groups of foamed concrete insulation block for the experiment arrangement were made.Through the test and analysis of test data，the most influential factors on compressive strength was confirmed.