Abstract: Taking food sensory teaching as an example, application of comprehensive experimental design based on cross fusion was expounded．Integrating and utilizing interdisciplinary knowledge and integrated design into comprehensive experiment．Students made samples by themselves, formulated sensory evaluation indicators of products, and evaluated quality of several products with different formulas．They used analysis of variance to give product evaluation results and judged significant differences between samples and reviewers．Experimental content covered a wide range of knowledge points．After several years of practice, students' comprehensive ability were improved, teaching effect feedback was good, and students' recognition was high．