Abstract: In order to inherit good quality of early maturing machine-picked cotton varieties and strains, 12 early maturing machine-picked cotton varieties from 10 regions in Northern Xinjiang were selected for regional experiments．Results showed that growth period of 12 varieties was 121.1 ～ 125.2 d, standard deviation was ±1.5 d, and early attribute was obvious．Cotton growth period of 10 experimental areas was 113.9 ～ 141.7 d, standard deviation was ±8.1 d．Uniformity of B10 in batting stage was the best．B07 seed cotton yield was the highest, 4.8% higher than B00（CK）．B09 lint cotton and frosted lint cotton were superior to other varieties, increasing yield by 10.0% and 9.7% compared with the control, respectively．Yield of intervariety lint cotton reached a significant level by variance analysis and t test．Lint cotton output ranked as B09 > B06 > B05 > B10 > B03 > B07 > B08 > B11 > B00> B04 > B02 > B01．Compared with B00, yield of B05 and B06 increased in all 10 experimental areas, while yield of other 10 varieties increased or decreased in different areas．Comprehensive evaluation of fiber quality detection, B04 and B00 were excellent cotton type Ⅰ standard, B02, B11, B05, B10, B06, B08, B09, B01, B03 were ordinary high quality type Ⅱ standard; B07 was quality Type III standard．Regional experimental results showed that, B09, B06 and B05 varieties could be popularized and cultivated in Northern Xinjiang．