Abstract: In response to problems of low yield, high equipment failure rate, easy blockage of mold holes, and poor molding rate in resource utilization process of agricultural solid waste such as solid manure, biomass straw, tea garden stems, orchard branches, sawdust, mushroom residue, etc．in production of biomass particles in large-scale aquaculture farms, LH-600 biomass granulation molding machine has been developed and designed．Innovative design was carried out on feeding device, particle forming device, and power transmission mechanism of molding machine, and Solidworks software was used for auxiliary design．The machine has been tested and applied in engineering practice, indicating that it has advantages of long service life, low maintenance cost, good lubrication and cooling effect of transmission mechanism, and efficient energy-saving lights．It is suitable for use in large and medium-sized feed processing plants, breeding farms, and organic fertilizer factories．