Abstract: Traditional irrigation and fertilization methods not only have low water and fertilizer utilization rates, waste labor and costs, but also pollute agricultural environment．Coupling technology of water and fertilizer achieves goal of improving water and fertilizer utilization efficiency, yield, quality, and reducing production costs through a reasonable ratio of irrigation and fertilization．Effects of water fertilizer coupling regulation on growth and development process, photosynthesis, yield, and quality of pumpkin was mainly reviewed．Results showed that reasonable water and fertilizer regulation could significantly promote growth, development, and photosynthesis of pumpkin, had a positive effect on dry matter accumulation, and improve yield and quality of pumpkin．Finally, promotion and application of water and fertilizer coupling technology in agricultural production were prospected．