Abstract: Selecting data from Shandong Province from 2012 to 2020, constructing a regional agricultural sustainable development indicator system in Shandong Province, and entropy method was used to comprehensively analyze and evaluate agricultural sustainable development of Shandong Province as a whole and various prefecture level cities．At the same time, using geographic differentiation maps and three-dimensional trend maps, spatial changes in level of sustainable agricultural development in Shandong Province was analyzed．Results showed that, overall level of agricultural sustainable development in Shandong Province was constantly improving, and gap of agricultural sustainable development between different regions was narrowing day by day．From perspective of spatial pattern distribution, sustainable agricultural development level of all prefecture-level cities in Shandong province was uneven and unbalanced, and two ends of sequence were stable．From the east-west perspective, level of comprehensive agricultural development transitioned smoothly from west to east, and eastern region was better than western region in a ladder shape．Trend of south and north was weaker than central region．There were still spatial differences among different regions, but pattern of spatial differences still existed．Based on research conclusions, some suggestions were put forward．Western region should rely on technological innovation to reform disadvantages of traditional agriculture and increase investment in modern agricultural machinery and equipment．Eastern region should rely on its unique resource advantages to speed up development of new technologies and products．Central region should rely on characteristics of its terrain to develop diversified new agricultural development modes．