Abstract: Engineering education should serve engineering practice．Under environment of engineering education reform and engineering certification in the new era, connotation of Engineering-with-a-Big-E of mechanical engineering talent training was explored, based on which a series of curriculum reform and practice of mechanical foundation were carried out．Taking mechanical foundation series courses of Xinjiang Agricultural University as an example, through research and analysis of demand side of talents, how to construct curriculum system and training mode suitable for training of first-class mechanical engineering professionals from aspects of curriculum group teaching structure, practical teaching, and innovative ability cultivation were investigated．Meanwhile, teaching team training mode of combination between traditional "old, middle-aged and young" mentors, utilize various aid policies for Xinjiang to further study backbone of teaching, and modern virtual instructional research platform were discussed, so as to support reform and practice of mechanical basic curriculum facing concept of Engineering-with-a-Big-E．