Abstract: By using three spray additives of Maifei, Nongjianfei, and Qigong, experiments on pesticide dosage reduction and efficiency increase were carried out, to verify and evaluate effect of three additives on pesticide dosage and efficacy in progress of maize diseases, pests, and weeds control, and to provide scientific basis for its popularization and application．Results showed that adding 225 mL/hm² of Maifei, 75 g/hm² of Nongjiangfei, or 150 mL/hm² of Qigong to 80% of local conventional spraying dosage had significantly higher efficacy than local conventional spraying dosage, and comprehensive economic benefits were also significantly improved．Thus, recommended dosage of three additives added to 80% of local conventional spraying dosage could significantly increase prevention effect of weeds and pests in maize, achieve purpose of reducing drugs and increasing efficiency, and improve comprehensive economic benefits of maize．It can be promoted and applied in practical production．