Abstract: Green and efficient prevention and control technology for cotton pests and diseases throughout process was deeply discussed, aiming at demonstrating and promoting advanced prevention and control strategies．Preparation work before sowing in the cotton demonstration area was introduced, including demonstration site, pre-sowing management, etc．A detailed exposotion was conducted on post-sowing management, such as seedling management, planting management, pest density, and comparative effects．Cotton yield comparison and results were analyzed．It was proposed to use demonstration zone as a promotional platform to promote green and efficient prevention and control technology throughout process, in order to improve yield and quality of cotton, reduce environmental pollution, and achieve sustainable development of agriculture．New ideas and methods for prevention and control of cotton diseases and pests were provided, and had important practical guidance significance．