Abstract: As a practical teaching component, experimental courses help students deeply understand and master professional theoretical knowledge, apply professional knowledge reasonably and effectively, improve engineering practice operation ability, and finally achieve educational objectives of higher education．Based on OBE concept and demands of related industrial development, teaching reform of professional comprehensive experimental courses in bioengineer major at Sichuan University of Science & Engineering was explored．Reform focused on aspects such as course teaching objectives, teaching contents, assessment methods, and course objectives' completion, to better help related professional talents training．