Abstract: Xinjiang Uygur Autonomous Region（abbreviated as Xinjiang）is vigorously promoting ten industrial clusters' construction, covering sectors such as energy, and specialty agricultural and pasture products processing, with remarkable results．Mechatronics technology, as core of modern manufacturing industry, plays a key supporting role in Xinjiang's ten industrial clusters．However, there currently exists a significant gap between cultivation of talent in mechatronics technology for industrial clusters and industrial demand．Facing ten characteristic industrial clusters in Xinjiang, course system construction and practice for Mechatronics Technology that integrates Xinjiang's regional characteristics should be developed．Cooperation and exchange between postgraduates and local enterprises should be strengthened, and close combination of theory and practice in Mechatronics Technology course should be promoted．Course has adopted consolidation-construction-integration as core teaching concept to explore teaching practice．This mainly included teaching cases' consolidation of mechatronics with regional characteristics in Xinjiang, an innovative experimental course system integrated virtual and physical was constructed, theoretical research and regional industry-academia-research integrated development in Xinjiang, to cultivate postgraduates talent for Xinjiang industrial development．