Abstract: Programmable Logic Controller and Application is a required course for majors in electrical engineering, automation, mechatronics, and other related．Higher education institutions focus on complex control theories and advanced programming techniques in courses, leading to issues such as students' insufficient interest and inadequate practical training．To effectively improve teaching quality, a virtual simulation+BOPPPS teaching method was proposed．Taking auxiliary relays and index registers as an example, Mitsubishi PLC series simulation software was adopted and integrated with six stages of BOPPPS teaching model to introduce design concept, teaching implementation process, and teaching effectiveness of virtual simulation + BOPPPS hybrid teaching mode．Results showed that proposed hybrid teaching mode effectively motivated students to participate enthusiastically, enhanced their practical operation skills, cultivated their innovative consciousness, and significantly improved teaching effectiveness．