Abstract: Numerical simulation methods are necessary CAD/CAE tools in moden engineering design. Simulation of existing products can validate the correctness of simulation methods, or found the defect of products. Simulation of existing products before alteration and scale up design could master the information in order to optimize the performance, lower the cost of design and manufacturing. In this paper, ANSYS was employed to analysis the static heat transfer of the wall of autoclave. In this way, we could master the rule of distribution of temperature. Furthermore, transient conduction of heat transfer between the fluid and the wall were simulated, It showed that the heat current layer of the methanol was very thin because of smallness of specific heat. It also showed the difference between water bath and electric heating by simulation of convection. All the work of simulation were aimed at offer basis theories and technology support of developing middle test set.