Abstract: The yield of Bombax ceiba polysaccharide was selected as investigation index，through single factor combined with response surface methodology，influence factor and optimum process of ultrasonic-microwave-assisted extraction of polysaccharide from Bombax ceiba were discussed.Results showed order of influence factors of ultrasonic-microwave-assisted extraction process was microwave power＞extraction time＞solid-to-liquid ratio.Optimal ultrasonic-microwave -assisted extraction conditions were solid-to-liquid ratio of 1∶40（g/mL），extraction time of 16 min，and microwave power of 202 W，and at this condition，yield of Bombax ceiba polysaccharide was 0.953%±0.015%.In addition，compared with traditional water extraction，ultrasonic-microwave-assisted extraction methods improved yield of Bombax ceiba polysaccharide in a shorter time，which has broad application prospect.