Abstract: Application history of ozone sterilization technology was introduced.Combining with the status quo of facility agriculture development in Fengtai district of Beijing，three different brands of ozone disinfection machine were chosen to carry out contrast experiment.Test results showed that ozone disinfection machine had certain effect on preventing diseases in bell pepper production，and improving product yield and quality.Promotion of ozone disinfection machine was recommended in several vegetable base in Fengtai distract.It would provide reference for facility agriculture pollution-free.