Abstract: As a special geological features in our country，the multiple geological disaster in the Karst region area has become the influence of "problems about agriculture，rural areas and peasantry"and the important factor of regional economic and social development.Based on the analysis of type and effect on regional economic and social of geological disaster in the Karst plateaux region，the control of geological disaster of landslide and collapse Dananshan primary in Yanzikou Town of Qixingguan District as an example，formation and control situation of landslide and collapse geological hazards were explored in the study area.The controlling measures of anti-sliding were including intercepting and drain system and blocking system，and engineering measures mainly included three kinds of intercepting drain，anti-slide pile and retaining wall.But collapse mainly adopted reinforce or cleaning.High incidence of landslide and collapse geological hazards was closely related to special geological features in Karst plateaux region.Finally，from two aspects of treating landslide and collapse geological disaster prevention，combining the reality of it，measures were put forward that strengthen regional geological disasters cruise screening，the design feasibility demonstration，and combination of returning farmland to forest policy measures to reduce the induced geological hazard，in order to reduce the impact of geological disasters on regional economic and social development.