Abstract: Microwave was used to extract total flavones from‘Dongzao’jujube leaves.Effects of the extraction parameters on the yield of total flavones from‘Dongzao’jujube leaves were studied，such as microwave temperature，microwave time， microwave power，liquid-solid ratio and ethanol concentration.Box-Behnken design and response surface analysis were adopted to establish regression equation of extraction of total flavones from‘Dongzao’jujube leaves on single factor tests.Optimal extraction conditions were microwave temperature 70 ℃，microwave time 6min，microwave power 500 W，liquid-solid ratio 60∶1 and ethanol concentration 50%.Under the conditions，the yield of total flavones was 3.760%，which was consistent with the predicted yield of total flavones of 3.757%.Results showed that the total flavones from leaves of‘Dongzao’jujube were studied.Results also showed that the total flavones had strong activity for hydroxyl radical scavenging，and had a good antioxidant activity.