Abstract: In the system of mist culture wall in the greenhouse，effects of different cultivation angle on large fast-growing lettuce were investigated.In this experimental treatment，engraftment angle 90°（with the horizontal plane angle，the following was the same）was not beneficial to growth of lettuce roots and the increase of lettuce blades’number，engraftment angle 90° of lettuce’s nitrate nitrogen content was low，meanwhile，compared with the horizontal engraftment angle 45°，chlorophyll content and soluble protein content of lettuce were decreased significantly.Horizontal engraftment angle 60° was beneficial to the growth of lettuce roots.Horizontal engraftment angle 45° was better for growth and quality of lettuce.Particularly，compared with the horizontal engraftment angle 45°，chlorophyll content and soluble protein content of lettuce significantly increased.Experiment showed that selecting the suitable engraftment angle was beneficial to cultivation of lettuce.Particularly，in the metope of cultivation，the engraftment angle 45°should be given priority.