Abstract: Through adsorption and desorption experiments，purification effects of anthocyanins extracted in mulberry were analyzed to screen for suitable macroporous resin for separation and purification of mulberry anthocyanins，and to establish purification process parameters.Results showed that XDA-6 resin was preferable for separation and purification of mulberry anthocyanins，with the dynamic adsorption conditions was that concentration 1.5 mgmL，original pH 3.5，desorption conditions was that ethanol concentration 60%.