Abstract: Based on status quo that biological engineering theoretical and experimental knowledge teaching inclined to traditional teaching mode and neglected to guide students，combining with characteristics of natural products technology course，several optimization methods and reform proposals were put forward.Based on age development，natural product micro class theory teaching and scientific research of complementary experimental operation go hand in hand，and it could promote development of experimental teaching abilities of scientific research.Training students to observe and analyze the basic ideas and rigorous scientific style could lay foundation of theory and skills to solve practical problems in production，scientific research.