Abstract: Due to serious overcapacity in China and continuous development of economy and society，people′s living standard is continuously improved and demands for products and consumption is getting higher and higher，but the market can not meet the demand.Agricultural supply-side reform is to improve quality and variety of products，to better serve consumers，so as to meet demand of market development.The economic pattern of agricultural cluster development has played a key role in promotion of agricultural supply-side reform.Problems encountered in agricultural supply-side reform and agricultural cluster development were discussed in view of special geographical environment and agricultural resource distribution in Guangxi，to provide some suggestions to facilitate smooth agricultural supply-side reform and agricultural economic development in Guangxi.