Abstract: In order to provide a suitable growth environment for crops and protect crops from impact of external climatic conditions and insect invasion，it is important to control micro-environment inside greenhouse.Micro-environment inside greenhouse includes environmental factors such as temperature，humidity and ventilation rate，which play an important role in crop growth.Computational fluid dynamics（CFD），as a numerical simulation technology，has been widely used in simulation of micro-environment in greenhouse in recent years.By using CFD to simulate micro-environment in greenhouse to realize visualization of flow field distribution in greenhouse，which is beneficial to optimize and improve environmental control measures.Research stituation of CFD in greenhouse ventilation and cooling at home and abroad in recent years were discussed.Furthermore，present situation of development in greenhouse micro-environment simulation，existing challenges and application prospect in the future were introduced.