Abstract: Innovation and entrepreneurship education and“double first-class”construction are the major deployment of national innovation driven development strategy and higher education reform.Taking Ankang University for example，development status of innovation and entrepreneurship education in local colleges were analyzed，and path choices of organic integration of innovation and entrepreneurship education and first-rate professional education in majors of agronomy were discussed.It has a certain theoretical and practical significance for increasing quality of applied innovative personnel training in local colleges.