Abstract: Based on investigation case of Weigan River irrigation district in Xayar County of Xinjiang, operation and management mode of leading agricultural enterprises was analyzed, basic laws, factor allocation and interest objectives of their production and operation were discussed, driving principle of leading agricultural enterprises entering upstream link of industrial chain was revealed, and adjustment of traditional water-saving management mode and change of governance behavior of agricultural leading enterprises were considered．Large-scale operation of leading agricultural enterprises is an important path to realize regional agriculture modernization．Vertical industrial integration promotes standardization and marketization of modern water-saving management．At the same time, improvement of water-saving management ability helps to realize benefit growth of industrial chain, thus forming a chain effect in agricultural industry chain．Large-scale operation of leading agricultural enterprises to promote application and promotion of high-efficiency water-saving technology has demonstrative significance and can be used as a model for other surrounding areas to learn from．