Abstract: Low temperature stress, including cold stress and freezing stress, which is one of the main factors causing crop yield reduction．It is of great significance to study low temperature response pathway regulated by transcription factor CBF for revealing molecular response of plants to low temperature stress．Research progress of plant cold resistance gene and ICE-CBF-COR signal pathway was reviewed from plant cold resistance gene, signal pathway, hormone and histone regulation and other aspects．Results showed that ICE-CBF-COR was central pathway for interaction of different transcription factors, regulatory factors, proteins, physiological factors and other manipulation factors to enhance cold stress．At the same time, it was also found that ICE-CBF-COR signal transduction pathway also played a crucial role in plant growth and development, flowering period regulation, fresh storage, genetic breeding and other related research, and prospect of future research and development was prospected．It is expected to provide reference and theoretical support for research of plant cold resistance genes, and also provide theoretical guidance for plant growth and development, flowering period regulation, fresh storage, genetic breeding．