Abstract: With development of science and technology, especially development of computer technology, it is possible to use computers as tools to study characteristics of real systems．Development of hydraulic simulation technology provides a good technical means for practice of the course "Hydraulic and Pneumatic Transmission"．Taking hydraulic system of harvester header as an example, application of AMESim simulation technology in practice of hydraulic and pneumatic transmission courses was introduced through header system analysis, hydraulic circuit design, AMESim modeling, and header lifting process simulation．This could provide a new method for practical reform of hydraulic and pneumatic transmission courses．