Abstract: Water shortage and low utilization rate of fertilizer are outstanding problems facing China's agricultural development．Integrated irrigation of water and fertilizer is an irrigation mode that integrates irrigation and fertilizer application into one, which can provide water and nutrients to roots of crops accurately in proportion and at regular intervals according to water and fertilizer demand rules of crops in different fertility periods．Research progress of integrated irrigation and related technologies of water and fertilizer at home and abroad, law of water and fertilizer demand during entire growth period of watermelon, and impact of integrated irrigation mode of water and fertilizer on growth, development, yield, and quality of watermelon, were summarized．Problems faced by integrated irrigation of water and fertilizer were analyzed, and relevant solutions were proposed．Deeply studying theory of integrated irrigation of water and fertilizer, optimizing irrigation equipment, and changing traditional irrigation and fertilization methods could provide theoretical basis for guiding water-saving, fertilizer saving, high-quality, and high-yield watermelon．