Abstract: Based on 30 m resolution land cover dynamic product data, a comprehensive methodology was employed, combining cultivated land abundance model, change rate model, gravity center migration model, standard deviation ellipse models, and spatial autocorrelation model, to quantitatively reveal their spatial distribution patterns, spatial-temporal migration pathways, and clustering characteristics of cultivated land non-agriculture and non-grain production in central Guizhou region．Furthermore, factors such as population, GDP, and topography were integrated to identify driving factors behind cultivated land non-agriculture and non-grain production within central Guizhou urban agglomeration．Results indicated that, ①from 2011 to 2021, cultivated land spatial distribution in central Guizhou urban agglomeration exhibited significant imbalance, with abundant cultivated land concentrated in central and northern parts of region．② From 2011 to 2021, both rates of non-agriculture and non-grain production of cultivated land in central Guizhou region exhibited significant spatial variation．Non-agriculture increased initially and then slowed, while non-grain production showed a persistent, gradual increase over decade．③ From 2011 to 2021, spatial gravity center of non-agriculture in central Guizhou urban agglomeration shifted toward the southeast, while that of non-grain production moved northward．④ From 2011 to 2021, spatial clustering of non-agriculture generally intensified, with high-high and low-low clustering zones located in north and center areas, respectively．In contrast, spatial clustering pattern of non-grain production showed a dispersed trend, with high-high and low-low clustering zones concentrated in west and center, respectively．⑤ Regarding driving factors, non-agriculture cultivated land was primarily driven by year-end resident population and public budget expenditure from 2011 to 2016, and public budget revenue and regional GDP became main driving factors from 2016 to 2021．No significant correlation between non-agriculture cultivated land and selected factors was observed throughout the study periodduring study period．